Preoperative serum levels of soluble endoglin for prediction of recurrence in stage III colorectal cancer patients

Title:

Preoperative serum levels of soluble endoglin for prediction of recurrence in stage III colorectal cancer patients
Preoperative serum levels of soluble endoglin for prediction of recurrence in stage III colorectal cancer patients

Creator:

Gomceli, Ismail, Tez, Mesut, Bostanci, Erdal B., Turhan, Nesrin, Kemik, Ahu S., and Akoglu, Musa

Contributor:

Gomceli, Ismail, Tez, Mesut, Bostanci, Erdal B., Turhan, Nesrin, Kemik, Ahu S., and Akoglu, Musa

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12036481-ceccb9e5-00f8-42d9-b17e-32f797c21f27
uuid:bmc12036481-ceccb9e5-00f8-42d9-b17e-32f797c21f27
local:bmc12036481
http://www.lfhk.cuni.cz/article.asp?nArticleID=6944&nLanguageID=2
local: bmc12036481

Subject:

dospělí, staří, staří nad 80 let, antigeny CD--krev, kolorektální nádory--chirurgie--krev--krevní zásobení--patologie, ženské pohlaví, lidé, mužské pohlaví, lidé středního věku, patologická angiogeneze--diagnóza, prognóza, receptory buněčného povrchu--krev, recidiva, and nádorové biomarkery--krev

Type:

model:article, article, Text, and TEXT

Format:

braille, text, and regular print

Description:

Background: To evaluate the clinical usefulness of serum levels of soluble form of endoglin in stage III colorectal adenocarcinomas (CRC) patients for detection of recurrence. Methods: The case-control study consisted of 80 stage III CRC patients who underwent surgery with curative intent and 70 age-and sex-matched healthy volunteers. Serum levels of soluble form of endoglin (sol-end) were measured in both groups. Also, predictive factors of recurrence were evaluated using multivariate analyses. Results: Serum levels of sol-end in stage III CRC patients were significantly higher than those in controls. There was not a significant association between serum levels of sol-end and clinicopathological features in CRC patients. Multivariate regression analysis showed the LN R (hazard ratio, 2.54; 95% CI , 1.46–4.34; p < 0.001), to be significant independent factors to estimate local recurrence in stage III CRC patients. Conclusion: Preoperative serum levels of sol-end do not seem useful as a marker for detection of recurrence in stage III CRC patients., Ismail Gomceli, Mesut Tez, Erdal B. Bostanci, Nesrin Turhan, Ahu S. Kemik, Musa Akoglu, and Literatura 18

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2012 Volume:55 | Number:2

Harvested from:

CDK

Metadata only:

false

Date:

2012