The effect of mud-bath therapy on bone status in rats during adjuvant subchronic arthritis

Title:

The effect of mud-bath therapy on bone status in rats during adjuvant subchronic arthritis
The effect of mud-bath therapy on bone status in rats during adjuvant subchronic arthritis

Creator:

Živná, Helena, Maric, Ljiljana, Gradošová, Iveta, Švejkovská, Klára, Hubená, Soňa, and Živný, Pavel

Contributor:

Živná, Helena, Maric, Ljiljana, Gradošová, Iveta, Švejkovská, Klára, Hubená, Soňa, and Živný, Pavel , 1961-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12040513-351e7bbb-c3b6-4740-a2a0-bc3370b295b0
uuid:bmc12040513-351e7bbb-c3b6-4740-a2a0-bc3370b295b0
local:bmc12040513
http://www.lfhk.cuni.cz/article.asp?nArticleID=4434&nDepartmentID=1288&nLanguageID=2
local: bmc12040513

Subject:

terapie bahnem, kosti a kostní tkáň--metabolismus, experimenty na zvířatech, artritida experimentální, zvířata, potkani Wistar, statistika jako téma, kostní denzita, osteoporóza, modely nemocí na zvířatech, biomechanika, fraktury femuru, and osteokalcin

Type:

model:article, article, Text, práce podpořená grantem, and TEXT

Format:

braille, text, and regular print

Description:

Introduction: We studied influence of mud-bath on bone status in male Wistar rats with subchronic arthritis. Methods: Arthritis was induced by 2 subplantar injections of Freund’s adjuvans with heat-killed Streptoccocus pyogenes into paw. Groups: intact (int) on chippings; (con) arthritis on chippings; (san38) arthritis on hot sand; (mu38) arthritis on hot mud; (mu21) arthritis on mild mud. Bone mineral density (BMD, g/cm2) was measured by dual energy X-ray absorptiometry and femurs were tested biomechanically. Bone markers osteocalcin (OC), PINP and CTX were analysed in bone. Results: BMD of right femur decreased vs. left in san38 (p = 0.030) and mu38 (p = 0.047). Fracture load of right/left femur (N) decreased in experimental groups, significantly in san38 (p = 0.05). Fracture threshold of neck decreased in right vs. left in experimental groups, but significantly in san38 (p = 0.05). OC decreased in mu38 vs. con (1.84 ± 0.14/2.62 ± 0.23). PINP decreased in int vs. san38 (p = 0.005) and mu21 (p < 0.001). CTX decreased in int vs. mu38 (p = 0.006) and mu21 (p = 0.005). Conclusion: The hot bath appears indifferent in relation to osteoporosis, while cold mud-bath shows good effect on bone metabolism. The cold mud-baths help to reduce arthritic inflammation and pain and thereby lead to higher mobility with positive consequence on bone., Helena Živná, Ljiljana Maric, Iveta Gradošová, Klára Švejkovská, Soňa Hubená, Pavel Živný, and Literatura 19

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2012 Volume:55 | Number:3

Harvested from:

CDK

Metadata only:

false

Date:

2012