The TT genotype of the MTHFR 677C > T polymorphism increases susceptibility to premature coronary artery disease in interaction with some of the traditional risk factors

Title:

The TT genotype of the MTHFR 677C > T polymorphism increases susceptibility to premature coronary artery disease in interaction with some of the traditional risk factors
The TT genotype of the MTHFR 677C > T polymorphism increases susceptibility to premature coronary artery disease in interaction with some of the traditional risk factors

Creator:

Sarecka-Hujar, Beata, Zak, Iwona, and Krauze, Jolanta

Contributor:

Sarecka-Hujar, Beata, Zak, Iwona, and Krauze, Jolanta

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc13037649-99326a78-3f72-4cc2-8f42-508ee960a7bf
uuid:bmc13037649-99326a78-3f72-4cc2-8f42-508ee960a7bf
local:bmc13037649
https://www.lfhk.cuni.cz/Faculty/Publications/Acta-Medica/Archive/
local: bmc13037649

Subject:

dospělí, nemoci koronárních tepen--genetika, ženské pohlaví, genetická predispozice k nemoci, genotyp, lidé, lipidy--krev, mužské pohlaví, methylentetrahydrofolátreduktasa (NADPH2)--genetika, polymorfismus genetický, rizikové faktory, and kouření

Type:

model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT

Format:

print, text, and regular print

Description:

BACKGROUND: The presence of several risk factors (genetic and non-genetic) has greater impact on the risk of premature coronary artery disease (CAD) than single risk factor. OBJECTIVE: The aim of the study was to establish possible relations between genotypes and alleles of 677C>T polymorphism of MTHFR gene and some traditional risk factors e.g. elevated levels of lipid parameters and smoking in development of premature CAD. METHODS: The groups comprised 152 patients with angiographically documented premature CAD (aged 42.9 +/- 5.5) and 121 age-matched blood donors (aged 42.3 +/- 6.5) were studied. The MTHFR 677C>T polymorphism was genotyped with Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. RESULTS: Patients with TT genotype who simultaneously smoked had increased risk of premature CAD compared to non-smoking cases with CC genotype (OR = 24.62). We also found that individuals with TT genotype and elevated LDL-cholesterol (LDL-chol.) level had significantly higher risk of CAD (OR = 9.92) than individuals with normal LDL-chol. level and CC genotype. CONCLUSIONS: The present study shows that simultaneous presence of MTHFR TT genotype and smoking or elevated levels of LDL-chol. influences the risk of premature CAD. This findings give interesting contribution to gene-environment interaction problem that may have clinical implications in the future. and B. Sarecka-Hujar, I. Zak, J. Krauze

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2012 Volume:55 | Number:4

Harvested from:

CDK

Metadata only:

false

Date:

2012