Tlymphocytes (CD3+HLA-DR+) in patients over 60 with mediterranean spotted fever

Title:

Tlymphocytes (CD3+HLA-DR+) in patients over 60 with mediterranean spotted fever
Changes in the T-lymphocytes (CD3+CD19-) and activated Tlymphocytes (CD3+HLA-DR+) in patients over 60 with mediterranean spotted fever

Creator:

Gospodinova, Margarita

Contributor:

Gospodinova, Margarita

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14045964-3902063f-7a7d-40dc-94ba-39f024ca1da4
uuid:bmc14045964-3902063f-7a7d-40dc-94ba-39f024ca1da4
local:bmc14045964
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
local: bmc14045964

Subject:

marseillská horečka--metabolismus--patofyziologie, imunitní systém--fyziologie, antigeny CD3--fyziologie, imunita buněčná, antigeny CD--fyziologie--metabolismus, T-lymfocyty--fyziologie--metabolismus, HLA-DR antigeny, rickettsiové infekce--diagnóza, statistika jako téma, dospělí, lidé, lidé středního věku, and mladý dospělý

Type:

model:article, article, Text, statistics, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

Mediterranean spotted fever (MSF) in Bulgaria shows increasing severity, especially in patients over sixty years. As T lymphocytes are the primary effector cells in MSF and are altered by the ageing process we aimed to specify the changes in their numbers in elderly patients. We performed a clinicoepidemiological study, haematological and biochemical analysis of 132 patients of 60+ and 30 patients between 19 and 57 years with MSF. We investigated the cell immunity of 20 patients of 60+ using immunofluocytometry. The control group consisted of 10 younger patients and 10 healthy individuals of 60+. MSF showed more unfavourable course in the elderly.We found T-lymphocytes depletion in all patients with MSF. Activated T lymphocytes were increased in elderly patients with MSF. We found significant differences between the number of activated T lymphocytes in elderly patients and healthy elderly persons. The observed T-lymphocytes depletion in MSF corresponded to the disease severity. The increase in the activated T lymphocytes in patients over 60 years contributes to an adequate immune response., Margarita Gospodinova, and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2011 Volume:2011 | Number:2

Harvested from:

CDK

Metadata only:

false

Date:

2011