Mitochondrial defects and their role in development of prostate cancer

Title:

Mitochondrial defects and their role in development of prostate cancer
Mitochondrial defects and their role in development of prostate cancer

Creator:

Kotrikadze, Nanuli, Alibegashvili, Nanana, Ramishvili, Liana, Gordeziani, Manana, Veshapidze, Nato, Chigogidze, Teimuraz, and Managadze, Laurent

Contributor:

Kotrikadze, Nanuli, Alibegashvili, Nanana, Ramishvili, Liana, Gordeziani, Manana, Veshapidze, Nato, Chigogidze, Teimuraz, and Managadze, Laurent

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14045972-097d1f93-a50c-4dba-9672-757d2786b41c
uuid:bmc14045972-097d1f93-a50c-4dba-9672-757d2786b41c
local:bmc14045972
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
local: bmc14045972

Subject:

DNA mitochondriální--genetika--metabolismus, nádory prostaty--genetika, reaktivní formy kyslíku, sukcinátdehydrogenáza--diagnostické užití, respirační komplex IV, glutathion--metabolismus, přenos energie, lidé, DNA mitochondriální--genetika--izolace a purifikace--metabolismus, citrátový cyklus, staří, mužské pohlaví, and lidé středního věku

Type:

model:article, article, Text, statistics, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

Introduction and Objectives: One of the characteristic changes of tumor formation is accumulation of genetic disorders in mitochondrial and nuclear genome. Mitochondrial disorders, from its side, are responsible for failure of metabolism, apoptosis, cell growth, formation of reactive oxygen species, etc. Overprpoduction of reactive oxygen species (ROS) significantly impacts the respiration chain enzymes and entirely the antioxidant system of mitochondria. Finally this may become a favorable condition for normal cells transformation. The purpose of the presented work was to study the mitochondrial defects and to establish their role in prostate cancer development. Results: Experimental results demonstrate significant increase of the activity of mitochondrial succinate dehydrogenaze (complex II) of the malignant epithelial cells of prostate, and slight changes in cytochrome oxydase (complex IV) activity. Also significant activation of the antioxidant system (glutathione-dependant system) of mitochondria in prostate malignant epithelial cells was revealed. Conclusion: The above mentioned mitochondrial changes (II and IV complexes of respiration chain, activity of the antioxidant system) partially demonstrate the alterations in mitochondrial energy metabolism, which from its side, may indicate to resistance of prostate cancer cells and correspondingly to intensification of proliferation processes., Nanuli Kotrikadze, Nanana Alibegashvili, Liana Ramishvili, Manana Gordeziani, Nato Veshapidze, Teimuraz Chigogidze, Laurent Managadze, and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2012 Volume:2012 | Number:3

Harvested from:

CDK

Metadata only:

false

Date:

2012