Potential chemopreventive effect of "Procont" on mirna expression in Cba/Ca mice

Title:

Potential chemopreventive effect of "Procont" on mirna expression in Cba/Ca mice
Potential chemopreventive effect of "Procont" on mirna expression in Cba/Ca mice

Creator:

Szirmai, Mónika, Juhász, Krisztina, Bertha, András, Gombos, Katalin, Gőcze, Katalin, Magda, Ingrid, Péter Révész, and Ember, István

Contributor:

Szirmai, Mónika, Juhász, Krisztina, Bertha, András, Gombos, Katalin, Gőcze, Katalin, Magda, Ingrid, Péter Révész, and Ember, István

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14045974-9477516a-9a7c-43d9-8c43-cf11a78d9aaa
uuid:bmc14045974-9477516a-9a7c-43d9-8c43-cf11a78d9aaa
local:bmc14045974
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
local: bmc14045974

Subject:

myši inbrední CBA, mikro RNA--analýza--účinky léků, regulace genové exprese--účinky léků, modely nemocí na zvířatech, 9,10-dimethyl-1,2-benzanthracen--škodlivé účinky, injekce intraperitoneální, léčivé přípravky, and zvířata

Type:

model:article, article, Text, statistics, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

Background: There is emerging molecular evidence concerning the modification of miR expression pattern after the treatment with chemopreventive agents. We investigated whether a potential chemopreventive agent called "Procont" deriving from a biological system has a positive effect on the DMBA induced dysregulation of let7 a, miR21 and miR146a miRNAs. Materials and Methods: CBA/CA H2k inbred mice were fed by Procont for 7 days before the intraperitoneal injection of DMBA. After one week of the beginning of Procont diet we analized the let7a, miR21, miR146a gene expression in vital organs of mice. Results: The Procont feeding significantly decreased all of the investigated miRNA expression compared with either the mice on a normal diet in the control group or mice were exposed to DMBA alone. Conclusion: The results indicate that "Procont" diet has a potential chemopreventive effect in mice exposed to DMBA., Mónika Szirmai, Krisztina Juhász, András Bertha, Katalin Gombos, Katalin Gőcze, Ingrid Magda, Péter Révész, István Ember, and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2012 Volume:2012 | Number:3

Harvested from:

CDK

Metadata only:

false

Date:

2012