Clinical significance of lymphocyte-platelet adhesion, cytokines and endothelial dysfunction in the development of gestational hypertension

Title:

Clinical significance of lymphocyte-platelet adhesion, cytokines and endothelial dysfunction in the development of gestational hypertension
Clinical significance of lymphocyte-platelet adhesion, cytokines and endothelial dysfunction in the development of gestational hypertension

Creator:

Matyakubova, Salomat Aleksandrovna

Contributor:

Matyakubova, Salomat Aleksandrovna

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc15010753-c6e05659-0787-43e3-8ad4-22818b6517df
uuid:bmc15010753-c6e05659-0787-43e3-8ad4-22818b6517df
local:bmc15010753
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
isrc: xxx
local: bmc15010753

Subject:

hypertenze indukovaná těhotenstvím--etiologie--patofyziologie--patologie, trombocyty - adhezivita, cytokiny--krev, endoteliální buňky, endotel--patologie, TNF-alfa--krev, lymfocyty--patologie, interleukiny--krev, rizikové faktory, oxid dusný--krev, mladiství, dospělí, ženské pohlaví, lidé, těhotenství, kohortové studie, and statistika jako téma

Type:

model:article, article, Text, hodnotící studie, and TEXT

Format:

electronic, electronic resource, remote, and elektronický zdroj

Description:

The aim of our study was to determine the significance of lymphocyte-platelet adhesion (LPA), interleukins, transforming included 139 pregnant women aged between 17 and 27 years (21.3±4.22 years). GH was diagnosed in 119 women after 20 weeks of pregnancy. 20 patients (control group) were with physiological course of pregnancy. The distribution of patients by groups was carried out according to the level of blood pressure (BP) in accordance with ICD-10 (Geneva, WHO, 2002). The survey was conducted at the moment of detection pregnancy from 7 to 10 weeks and in dynamics of I, II and III trimesters of gestation. In the dynamics of gestation, were studied the number of desquamated endothelial cells circulating in the systemic circulation (CECs), nitrates levels, the adhesion of platelets by estimation their ability to form co-aggregates with lymphocytes by determining the percentage of lymphocytes aggregates with thrombocytes (lymphocyte-platelet plugs), at risk of hypertensive disorders, especially after 20-22 weeks of gestation and later, lymphocytes ability to platelets adhesion is rose, the concentrations of pro-inflammatory cytokines and NO level are increased. The direct relationship indicates their importance in the pathogenesis of hypertensive disorders in pregnant women., Salomat Aleksandrovna Matyakubova, and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2014 Volume:7 | Number:2

Harvested from:

CDK

Metadata only:

false

Date:

2014