Melatonin regulates oxidative stress initiated by Freund's complete adjuvant

Title:

Melatonin regulates oxidative stress initiated by Freund's complete adjuvant
Melatonin regulates oxidative stress initiated by Freund's complete adjuvant

Creator:

Pohanka, Miroslav, Ruttkay-Nedecký, Branislav, Fusek, Josef, Adam, Vojtěch, and Kizek, René

Contributor:

Pohanka, Miroslav, Ruttkay-Nedecký, Branislav, Fusek, Josef , 1945-, Adam, Vojtěch , 1982-, and Kizek, René , 1972-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc15040793-0bb64384-55d8-46ef-a9fb-74051f9c6b62
uuid:bmc15040793-0bb64384-55d8-46ef-a9fb-74051f9c6b62
local:bmc15040793
http://actamedica.lfhk.cuni.cz/
doi: 10.14712/18059694.2015.87
local: bmc15040793

Subject:

adjuvancia imunologická--farmakologie, zvířata, antioxidancia--farmakologie--fyziologie, vztah mezi dávkou a účinkem léčiva, ženské pohlaví, Freundovo adjuvans--farmakologie, melatonin--farmakologie--fyziologie, myši, and oxidační stres--účinky léků--fyziologie

Type:

model:article, article, Text, časopisecké články, and TEXT

Format:

print, text, and regular print

Description:

Melatonin is a hormone with strong antioxidant properties. In this experiment, Freund's complete adjuvant was used as a stressogenic substance given to laboratory outbred mice, whereas melatonin was investigated as a protectant against the stressogenic effect. Levels of low molecular weight antioxidants, thiobarbituric acid reactive substances, and tumor necrosis factor α and activity of glutathione reductase were determined in blood from the animals. Surprisingly, melatonin was not involved in direct regulation of antioxidants, thiobarbituric acid reactive substances and tumor necrosis factor α. On the other hand, melatonin regulated glutathione reductase activity. We can conclude on regulation of metabolism caused by melatonin in the model. The effect was more important than the expected regulation of immunity and basal oxidative homeostasis. and M. Pohanka, B. Ruttkay-Nedecký, J. Fusek, V. Adam, R. Kizek

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2015 Volume:58 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2015