The evaluation of the potency of newly developed oximes (K727, K733) and Trimedoxime to counteract acute neurotoxic effects of tabun in rats

Title:

The evaluation of the potency of newly developed oximes (K727, K733) and Trimedoxime to counteract acute neurotoxic effects of tabun in rats
The evaluation of the potency of newly developed oximes (K727, K733) and Trimedoxime to counteract acute neurotoxic effects of tabun in rats

Creator:

Kassa, Jiří, Hatlapatková, Jana, and Žďárová, Jana

Contributor:

Kassa, Jiří , 1956-, Hatlapatková, Jana, and Žďárová, Jana , 1982-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc16019677-1901d11c-82d8-47dd-b9fd-278eaf0777f8
uuid:bmc16019677-1901d11c-82d8-47dd-b9fd-278eaf0777f8
local:bmc16019677
http://actamedica.lfhk.cuni.cz/
doi: 10.14712/18059694.2016.6
local: bmc16019677

Subject:

zvířata, atropin--farmakologie, inhibitory cholinesteráz--toxicita, cholinesterasové reaktivátory--farmakologie, mužské pohlaví, antagonisté muskarinových receptorů--farmakologie, nervový systém--účinky léků, neuroprotektivní látky--farmakologie, neurotoxické syndromy--farmakoterapie--etiologie, otrava organofosfáty--farmakoterapie--etiologie, organofosfáty--toxicita, oximy--farmakologie, pyridinové sloučeniny--farmakologie, krysy, potkani Wistar, and trimedoxim--farmakologie

Type:

model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT

Format:

print, text, and regular print

Description:

AIM: The ability of two newly developed oximes (K727, K733) to reduce tabun-induced acute neurotoxic signs and symptoms was evaluated and compared with currently available trimedoxime in rats. METHODS: The neuroprotective effects of the oximes studied combined with atropine on Wistar rats poisoned with tabun at a lethal dose (380 µg/kg i.m.; 90% of LD50 value) were evaluated. Tabun-induced neurotoxicity was monitored by the functional observational battery consisting of 38 measurements of sensory, motor and autonomic nervous functions at 2 hours following tabun challenge. RESULTS: All tested oximes combined with atropine enable tabun-poisoned rats to survive till the end of experiment. Both newly developed oximes (K727, K733) combined with atropine were able to decrease tabun-induced neurotoxicity in the case of lethal poisoning although they did not eliminate all tabun-induced acute neurotoxic signs and symptoms. CONCLUSION: The ability of both novel bispyridinium oximes to decrease tabun-induced acute neurotoxicity was slightly lower than that of trimedoxime. Therefore, the newly developed oximes are not suitable for the replacement of commonly used oximes such as trimedoxime in the treatment of acute tabun poisonings. and J. Kassa, J. Hatlapatková, J. Žďárová Karasová

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2015 Volume:58 | Number:4

Harvested from:

CDK

Metadata only:

false

Date:

2015