Early rehabilitation model shows positive effects on neural degeneration and recovery from neuromotor deficits following traumatic brain injury

Title:

Early rehabilitation model shows positive effects on neural degeneration and recovery from neuromotor deficits following traumatic brain injury

Creator:

Marcela Lippert-Grüner, Maegele, M., Jaroslav Pokorný, Angelov, D. N., Olga Švestková, Michal Wittner, and Stanislav Trojan

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c3281b4d-1a89-4c48-8121-8332529da720
uuid:c3281b4d-1a89-4c48-8121-8332529da720
issn:0862-8408

Subject:

Patologie. Klinická medicína, neurorehabilitace, poranění mozku, léčebná rehabilitace, neurorehabilitation, brain injuries, therapeutic rehabilitation, motor dysfunction, neural loss, 14, and 616

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

This study used an experimental early rehabilitation model combining an enriched environment, multisensory (visual, acoustic and olfactory) stimulation and motor training after traumatic brain injury (via fluid-percussion model) to simulate early multisensory rehabilitation. This therapy will be used by brain injured patients to improve neural plasticity and to restore brain integration functions. Motor dysfunction was evaluated using a composite neuroscore test. Direct structural effects of traumatic brain injury were examined using Fluoro-Jade staining, which allows identification of degenerating neural cell bodies and processes. Animals in the rehabilitation model group performed significantly better when tested for neuromotor function than the animals in standard housing in the 7-day and 15-day interval after injury (7d: p=0.005; 15d: p<0.05). Statistical analysis revealed significantly lower numbers of Fluoro-Jade positive cells (degenerating neurons) in the rehabilitation model group (n=5: mean 13.4) compared to the standard housing group (n=6: mean 123.8) (p<0.005). It appears that the housing of animals in the rehabilitation model led to a clear functional increase in neuromotor functions and to reduced neural loss compared with the animal group in standard housing., M. Lippert-Grüner. M. Maegele, J. Pokorný, D. N. Angelov, O. Švestková, M. Wittner, S. Trojan., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:3

Harvested from:

CDK

Metadata only:

false