Hyperinsulinemia and Oxidative Stress
- Title:
- Hyperinsulinemia and Oxidative Stress
- Creator:
- Pavlína Kyselová, Michal Žourek, Zdeněk Rušavý, Ladislav Trefil, and Jaroslav Racek
- Identifier:
- https://cdk.lib.cas.cz/client/handle/uuid:c3431010-6a05-43bc-982f-67ae80621711
uuid:c3431010-6a05-43bc-982f-67ae80621711
issn:0862-8408 - Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Oxidative stress, Hyperglycemia, Hyperinsulinemia, Rat, 14, and 612
- Type:
- article, studie, model:article, and TEXT
- Format:
- print, bez média, and svazek
- Description:
- The aim of the study was to compare the effect of short-term hyperglycemia and short-term hyperinsulinemia on parameters of oxidative stress in Wistar rats. Twenty male rats (aged 3 months, average body weight 325 g) were tested by hyperinsulinemic clamp (100 IU/l) at two different glycemia levels (6 and 12 mmol/l). Further 20 rats were used as a control group infused with normal saline (instead of insulin) and 30 % glucose simultaneously. Measured parameters of oxidative stress were malondialdehyde (MDA), reduced glutathione (GSH) and total antioxidant capacity (AOC). AOC remained unchanged during hyperglycemia and hyperinsulinemia. Malondialdehyde (as a marker of lipid peroxidation) decreased significantly (p<0.05) during the euglycemic hyperinsulinemic clamp, and increased significantly during isolated hyperglycemia without hyperinsulinemia. Reduced glutathione decreased significantly (p<0.05) during hyperglycemia without hyperinsulinemia. These results suggest that the short-term exogenous hyperinsulinemia reduced the production of reactive oxygen species (ROS) during hyperglycemia in an animal model compared with the control group., P. Kyselová, M. Žourek, Z. Rušavý, L. Trefil, J. Racek., and Obsahuje bibliografii
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public - Source:
- Physiological research | 2002 Volume:51 | Number:6
- Harvested from:
- CDK
- Metadata only:
- false
The item or associated files might be "in copyright"; review the provided rights metadata:
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- policy:public