Insulin Resistance and Vitamin D Deficiency in Patients With Chronic Kidney Disease Stage 2-3

Title:

Insulin Resistance and Vitamin D Deficiency in Patients With Chronic Kidney Disease Stage 2-3

Creator:

Štefíková, Kornélia, Viera Spustová, Zora Krivošíková, Adrian Okša, Katarína Gazdíková, Viera Fedelešová, and Rastislav Dzúrik

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c52668f3-3f3e-40f2-a8f8-0c0283574ac0
uuid:c52668f3-3f3e-40f2-a8f8-0c0283574ac0

Subject:

Biologické vědy, fyziologie, physiology, chronic kidney disease, insulin resistance, 25(OH) vitamin D, 1,25(OH)2 vitamin D, proteinuria, 2, and 57/59

Type:

article, články, model:article, and TEXT

Description:

Vitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3. Insulin sensitivity/resistance was calculated by the quantitative insulin sensitivity check index (QUICKI). In this analysis, the prevalence of insulin resistance was 42 %. Only 17 % of patients had serum 25(OH) vitamin D concentration in the recommended range ( ≥ 30 ng/ml), 42 % suffered from vitamin D insufficiency and 41 % had moderate vitamin D deficiency. Insulin resistance significantly correlated with serum 25(OH)D and 1,25(OH) 2 D concentrations, renal function and protein excretion rate. Our results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease. and K. Štefíková ... [et al.].

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:1

Harvested from:

CDK

Metadata only:

false