Zinc and copper in the tissues and serum of cadmium intoxicated Guinea-pigs: influence of vitamin C

Title:

Zinc and copper in the tissues and serum of cadmium intoxicated Guinea-pigs: influence of vitamin C

Creator:

Kadrabová, J., Maďarič, A., and Ginter, E.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c665d22d-7bd5-4e12-8feb-d2eedeccb2a8
uuid:c665d22d-7bd5-4e12-8feb-d2eedeccb2a8

Subject:

cadmium, zinc, copper, copper deficiency, vitamin C, and Guinea-pigs

Type:

article, model:article, and TEXT

Description:

Cadmium in the dose of 1 mg/animal/day was administered to guinea-pigs in the form of CdCl2 dissolved in drinking water during short-term (5 weeks) and subchronic (12 weeks) experiments. Both the control and cadmium-treated groups were divided into two subgroups, according to low (2 mg/animal/day) and high (100 mg/animal/day) vitamin C intake. Subchronic cadmium treatment caused copper deficiency indicated by a dramatic decrease of copper concentration in the liver and serum and by its moderate decrease in the testes and brain. Cadmium significantly increased zinc concentrations in the kidneys during the whole experiment and decreased the level of zinc in the serum after subchronic cadmium treatment. In the control groups, the levels of zinc and copper in the serum were lowered after 5 weeks of high vitamin C doses. High doses of vitamin C in cadmium-treated guinea-pigs decreased the levels of copper in the testes, brain and serum. These observations suggest that cadmium intake in relatively high doses might potentiate the development of copper deficiency, and high doses of vitamin C aggravate, to a certain extent, copper depletion in some important organs and serum of guinea-pigs.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1993 Volume:42 | Number:4

Harvested from:

CDK

Metadata only:

false