Healthy microbiome - a mere idea or a sound concept?

Title:

Healthy microbiome - a mere idea or a sound concept?

Creator:

Najmanová, Lucie, Vídeňská, Petra, and Cahová, Monika

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c85d9d7f-9ba5-4883-b690-ccf820627676
uuid:c85d9d7f-9ba5-4883-b690-ccf820627676
doi:10.33549/physiolres.934967

Subject:

holobiont, core microbiome function, resilience, microbiome ecology, one health hypothesis, and dysbiosis

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Hundreds of studies in last decades have aimed to compare the microbiome of patients suffering from diverse diseases with that of healthy controls. The microbiome-related component was additionally identified in pathophysiology of many diseases formerly considered to depend only on the host physiology. This, however, opens important questions like: “What is the healthy microbiome?” or “Is it possible to define it unequivocally?”. In this review, we describe the main hindrances complicating the definition of “healthy microbiome” in terms of microbiota composition. We discuss the human microbiome from the perspective of classical ecology and we advocate for the shift from the stress on microbiota composition to the functions that microbiome ensures for the host. Finally, we propose to leave the concept of ideal healthy microbiome and replace it by focus on microbiome advantageous for the host, which always depends on the specific context like the age, genetics, dietary habits, body site or physiological state.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

719-738

Source:

Physiological research | 2022 Volume:71 | Number:6

Harvested from:

CDK

Metadata only:

false