Serum omentin levels in adolescent girls with anorexia nervosa and obesity

Title:

Serum omentin levels in adolescent girls with anorexia nervosa and obesity

Creator:

Oświęcimska, J., Suwała, A., Świętochowska, E., Ostrowska, Z., Gorczyca, P., Ziora-Jakutowicz, K., Machura, E., Szczepańska, M., Kukla, M., Stojewska, M., Ziora, D., and Ziora, K.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c908dfa0-763e-40f2-ba1e-9985cc162d69
uuid:c908dfa0-763e-40f2-ba1e-9985cc162d69
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, mentální anorexie, obezita, poruchy příjmu potravy, dospívající dívky, inzulin, anorexia nervosa, obesity, eating disorders, adolescent girls, insulin, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

It is believed that omentin is secreted by stromal cells of adipose tissue and modulates insulin se nsitivity. Data from a few studies have shown lower serum omentin in obese children and higher in anorexia nervosa. However, to date, there is lack of research on serum omentin concentrations in adolescent patients in a wide range of body mass index (BMI) and insulin resistance. In this cross -sectional study omentin -1 serum concentrations were evaluated using commercially available ELISA kit in 47 Polish girls with restrictive anorexia nervosa (AN), 50 with simple obesity (OB) and 39 healthy controls (C). T he mean serum omentin -1 concentration in girls with AN was statistically significantly higher than that of C and OB girls. Statistically significant (P<0.0001) negative correlations between the serum concentrations of omentin- 1 and body weight (r= - 0.73), BMI (r= - 0.75), standard deviation score for body mass index (BMI -SDS) (r= - 0.75), insulin (r= - 0.81) and HOMA -IR index (r= - 0.82) were seen in the entire examined population. We conclude, that omentin -1 is the nutritional marker reflecting body weight and insulin resistance. Our findings support the hypothesized role of omentin in maintenance of body weight and regulation of appetite and suggest the adaptation of its secretion to body weight and glucose metabolism., J. Oświęcimska, A. Suwała, E. Świętochowska, Z. Ostrowska, P. Gorczyca, K. Ziora-Jakutowicz, E. Machura, M. Szczepańska, M. Kukla, M. Stojewska, D. Ziora, K. Ziora., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:5

Harvested from:

CDK

Metadata only:

false