Models of epileptic seizures in immature rats

Title:

Models of epileptic seizures in immature rats

Creator:

Pavel Mareš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c9167102-8e51-4957-b35e-cb21d4a0c485
uuid:c9167102-8e51-4957-b35e-cb21d4a0c485

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, rat, ontogeny, epileptic seizures, convulsant drugs, electrical stimulation, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Models of basic types of epileptic seizures are elaborated not only in adult but also in immature rodents. It is important because at least half of human epilepsies starts during infancy and childhood. This paper presents a review of chemically and electrically induced models of generalized convulsive and nonconvulsive (absence) seizures as well as models of partial simple (neocortical) and complex (limbic) seizures in immature rats. These models can also serve as a tool for study the development of central nervous system and motor abilities because the level of maturation is reflected in seizure semiology. Age-dependent models of epileptic seizures (absences and flexion seizures) are discussed. Models of seizures in immature animals should be used for testing of potential antiepileptic drugs., P. Mareš., and Obsahuje seznam literaury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false