Liver, plasma and erythrocyte phospholipid content after chronic diazepam treatment in the rat

Title:

Liver, plasma and erythrocyte phospholipid content after chronic diazepam treatment in the rat

Creator:

Vrbaški, S. R., Ristić, V., Petrović, G., Tepšić, V., and De Luka, S. R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cb16d2e4-72a1-4f72-85d8-9c99df7a0c02
uuid:cb16d2e4-72a1-4f72-85d8-9c99df7a0c02

Subject:

diazepam, liver, and plasma and erythrocyte phospholipids

Type:

article, model:article, and TEXT

Description:

Male Wistar rats were maintained on a nutritionally adequate diet and diazepam was administered in a dose of 10 mg/kg/day. Control animals were pair-fed an adequate diet. Feeding was continued for 180 days, and the effects on the liver, plasma and erythrocyte phospholipid content were studied. It was found that the contents of sphingophospholipids and phosphatidylinositol + phosphatidylserine were significantly reduced in the erythrocytes of diazepam-treated rats. There was a significantly increased content of phosphatidylcholine in the liver and erythrocytes after 180 days of diazepam treatment. Such treatment did not cause statistically significant changes in the plasma of diazepam-treated rats. These investigations are in agreement with the hypothesis that extended or chronic use of drugs such as diazepam may alter membrane-dependent processes.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1996 Volume:45 | Number:1

Harvested from:

CDK

Metadata only:

false