Comparison of total and salivary cortisol in a low-dose ACTH (synacthen) test: Influence of three-month oral contraceptives administration to healthy women

Title:

Comparison of total and salivary cortisol in a low-dose ACTH (synacthen) test: Influence of three-month oral contraceptives administration to healthy women

Creator:

Kateřina Šimůnková, Luboslav Stárka, Martin Hill, Lubomír Kříž, Richard Hampl, and Karel Vondra

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cbc40ded-190f-452e-966a-2a2291bcb076
uuid:cbc40ded-190f-452e-966a-2a2291bcb076
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, endokrinologie, kortizol, antikoncepce, endocrinology, cortisol, contraception, low dose ACTH test, salivary cortisol, total serum cortisol, free cortisol, cortisol binding globulin, oral contraceptives, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The objective of this study was to evaluate the influence of low-dose combined oral contraception (COC) on basal and stimulated (1 μg ACTH test) levels of serum and salivary cortisol (F), cortisone and on basal serum cortisol binding globulin (CBG), adrenocorticotropic hormone (ACTH), dehydroepiadrosterone (DHEA) and calculated free cortisol in healthy young women. Three-month administration of COC resulted in 1) significant increase of basal (454.0±125.0 to 860.9±179.7 nmol/l) and ACTH-stimulated serum cortisol in 30th min (652.3±60.5 to 1374.1±240.6 nmol/l); 2) no significant change of basal (15.4±7.3 to 18.9±8.5 nmol/l) and ACTH-stimulated salivary cortisol at the 30th min (32.4±8.8 to 32.9±9.0 nmol/l); 3) no significant change of basal serum cortisone (38,8±7.68 to 45.2±24.2 nmol/l) and ACTH-stimulated cortisone at the 30th (34.8±10.9 to 47.0±35.7 nmol/l); 4) significant increase of basal ACTH (17.2±9.0 to 38.2±29.4 ng/l), CBG (991.0±161.0 to 2332.0±428.0 nmol/l), and 5) no significant change of basal DHEA (24.6±15.7 to 22.6±11.7 μmol/l) and calculated basal value for free cortisol (22.8±14.9 to 19.2±6.9nmol/l). In conclusions, higher basal and ACTH-stimulated serum cortisol were found after three-month administration of COC, while basal and stimulated salivary cortisol were not significantly affected. Therefore, salivary cortisol can be used for assessment of adrenal function in women regularly using COC., K. Šimůnková, L. Stárka, M. Hill, L. Kříž, R. Hampl, K. Vondra., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false