Allopurinol intake does not modify the slow component of V O2 kinetics and oxidative stress induced by severe intensity exercise

Title:

Allopurinol intake does not modify the slow component of V O2 kinetics and oxidative stress induced by severe intensity exercise

Creator:

Olek, R. A., Safranow, K., Jakubowska, K., Olszewska, M., Chlubek, D., and Laskowski, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cbea1a43-765f-44be-87e0-e47fc8cf2d4c
uuid:cbea1a43-765f-44be-87e0-e47fc8cf2d4c

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, xanthine oxidase, total antioxidant status, reactive oxygen species, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

The aim of this study was to test the hypothesis that allopurinol ingestion modifies the slow component of • VO2 kinetics and changes plasma oxidative stress markers during severe intensity exercise. Six recreationally active male subjects were randomly assigned to receive a single dose of allopurinol (300 mg) or a placebo in a double-blind, placebo-controlled crossover design, with at least 7 days washout period between the two conditions. Two hours following allopurinol or placebo intake, subjects completed a 6-min bout of cycle exercise with the power output corresponding to 75 % • VO2 max. Blood samples were taken prior to commencing the exercise and then 5 minutes upon completion. Allopurinol intake caused increase in resting xanthine and hypoxanthine plasma concentrations, however it did not affect the slow component of oxygen uptake during exercise. Exercise elevated plasma inosine, hypoxanthine, and xanthine. Moreover, exercise induced a decrease in total antioxidant status, and sulfhydryl groups. However, no interaction treatment x time has been observed. Short term severe intensity exercise induces oxidative stress, but xanthine oxidase inhibition does not modify either the kinetics of oxygen consumption or reactive oxygen species overproduction., R. A. Olek ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:1

Harvested from:

CDK

Metadata only:

false