Increased plasma levels of the high mobility group box 1 protein (HMGB1) are associated with a higher score of gastrointestinal dysfunction in individuals with autism

Title:

Increased plasma levels of the high mobility group box 1 protein (HMGB1) are associated with a higher score of gastrointestinal dysfunction in individuals with autism

Creator:

Katarína Babinská, Mária Bucová, Vladimíra Ďurmanová, Lakatošová, S., Daniela Jánošíková, Bakoš, J., Anna Hlavatá, and Daniela Ostatníková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cd1e3ca4-0901-4f3e-a74c-31851aa4edc4
uuid:cd1e3ca4-0901-4f3e-a74c-31851aa4edc4
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, autismus, záněty, autism, inflammations, HMGB1 plasma levels, gastrointestinal symptoms, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Autism is a disorder of neural development characterized by impairments in communication, social interaction, restricted interests and repetitive behavior. The etiology of autism is poorly understood, the evidence indicates that inflammation may play a key role. In autism a high prevalence of gastrointestinal disturbances is reported, that are linked to a low-grade chronic inflammation of the intestinal mucosa. High mobility group box 1 protein (HMGB1) is an intranuclear protein that can be passively released from necrotic cells or actively secreted under inflammatory conditions as alarmin or late proinflammatory cytokine. The objective of this study was to measure plasma levels of HMGB1 in individuals with autism and to analyze their association with gastrointestinal symptoms. The study involved 31 subjects with low-functioning autistic disorder aged 2-22 years and 16 healthy controls. Plasma HMGB1 levels were significantly higher in individuals with autism than in controls (13.8±11.7 ng/ml vs. 7.90±4.0 ng/ml, p<0.02). In subjects with plasma HMGB1levels higher than 11 ng/ml severe forms of GI disorders were more prevalent (83.3 %) than in subjects with lower levels (38.9 %, p<0.04). Results of the study support the involvement of the systemic low-grade inflammation in the pathomechanisms of autism and its possible association with GI symptoms., K. Babinská, M. Bucová, V. Ďurmanová, S. Lakatošová, D. Jánošíková, J. Bakoš, A. Hlavatá, D. Ostatníková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false