proBDNF is a major product of bdnf gene expressed in the perinatal rat cortex

Title:

proBDNF is a major product of bdnf gene expressed in the perinatal rat cortex

Creator:

Menshanov, P. N., Lanshakov, D. A., and Dygalo, N. N.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cd62011e-c3b5-449b-a484-91b5d3c55885
uuid:cd62011e-c3b5-449b-a484-91b5d3c55885
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, mozková kůra, cerebral cortex, developing brain, proBDNF, mBDNF, active caspase-3, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

In the developing brain, mature brain derived neurotrophic factor (mBDNF) and its precursor (proBDNF) exhibit prosurvival and proapoptotic functions, respectively. However, it is still unknown whether mBDNF or proBDNF is a major form of neurotrophin expressed in the immature brain, as well as if the level of active caspase -3 correlates with the levels of BDNF forms during normal brain development. Here we found that both proBDNF and mBDNF were expressed abundantly in the rat brainstem, hippocampus and cerebellum between embryonic day 20 and postnatal day 8. The levels of mature neurotrophin as well as mBDNF to proBDNF ratios negatively correlated with the expression of active caspase -3 across brain regions. The immature cortex was the only structure, in which proBDNF was the major product of bdnf gene, especially in the cortical layers 2-3. And only in the cortex, the expression of BDNF precursor positive ly correlated with the levels of active caspase -3. These findings suggest that proBDNF alone may play an important role in the regulation of naturally occurring cell death during cortical development., P. N. Menshanov, D. A. Lanshakov, N. N. Dygalo., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:6

Harvested from:

CDK

Metadata only:

false