Effect of quercetin on daunorubicin-induced heart mitochondria changes in rats

Title:

Effect of quercetin on daunorubicin-induced heart mitochondria changes in rats

Creator:

Juraj Guzy, Jaroslav Kušnír, Mária Mareková, Chavková, Z., Katarína Dubayová, Mojžišová, G., Ladislav Mirossay, and Ján Mojžiš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cd931943-017c-40bb-a249-5c16b14cb7f0
uuid:cd931943-017c-40bb-a249-5c16b14cb7f0
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, mitochondrie, mitochondrias, antioxidant enzymes, daunorubicin, quercetin, synchronous fluorescence spectra, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Cancer therapy with daunorubicin is limited by its cardiotoxicity. It has been suggested that daunorubicin-induced free radical generation can be involved. The precise molecular mechanism of daunorubicin-induced cardiotoxicity is still not well understood but it is believed that mitochondria play an important role in this process. It has been reported that flavonoids with antioxidant properties may prevent anthracycline-induced cardiotoxicity. In this work, we investigated the effects of daunorubicin and quercetin on mitochondrial enzyme activities such as ATPase, glutathione peroxidase (GPx) and glutathione reductase (GR). Moreover, we also studied the changes of outer mitochondrial membrane using synchronous fluorescence spectra. The actitivity of ATPase and GR were significantly increased after daunorubicin application. Pretreatment with quercetin significantly alleviated this increase. On the other hand, GPx activity was significantly decreased and quercetin prevented this decrease. Treatment with quercetin alone had no significant effect on the enzyme activity studied. Quercetin also completely prevented daunorubicin-induced changes in fluorescence of the outer mitochondrial membrane. In conclusion, our data indicate that quercetin may be useful in mitigating daunorubicin-induced cardiotoxicity., J. Guzy, J. Kušnír, M. Mareková, Z. Chavková, K. Dubayová, G. Mojžišová, L. Mirossay, J. Mojžiš., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:6

Harvested from:

CDK

Metadata only:

false