Cytosolic free calcium response to angiotensin II in aortic VSMC isolated from male and female SHR

Title:

Cytosolic free calcium response to angiotensin II in aortic VSMC isolated from male and female SHR

Creator:

Loukotová, J., Kuneš, J., and Zicha

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ce94df44-aae0-4f8e-96c5-6c77ec91d47d
uuid:ce94df44-aae0-4f8e-96c5-6c77ec91d47d

Subject:

spontaneously hypertensive rat, gender, primary culture, VSMC, angiotensin II, and cytosolic free calcium

Type:

article, model:article, and TEXT

Description:

Previous in vitro studies have shown that vascular smooth muscle cells (VSMC) isolated from the aortae of male spontaneously hypertensive rats (SHR) proliferate more rapidly than those obtained from female SHR. Sex-dependent differences of cytosolic free calcium concentration ([Ca2+]j) were therefore studied in VSMC under basal conditions and after the stimulation by different concentrations of angiotensin II (Ang II). No significant difference in basal [Ca2+]i was found in VSMC from male and female SHR. Angiotensin II significantly increased |Ca2+], in VSMC from both genders. This [Ca2+]j rise elicited by 10'7 and 10~9 M Ang II was more pronounced in cells isolated from males than in those from females. This difference may be attributed to greater mobilisation of intracellular calcium stores in male VSMC. It can be concluded that the cytosolic free calcium response to angiotensin II is augmented in VSMC of male SHR, which also grow more rapidly in response to this peptide hormone.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1998 Volume:47 | Number:6

Harvested from:

CDK

Metadata only:

false