Statin-associated myopathy: from genetic predisposition to clinical management

Title:

Statin-associated myopathy: from genetic predisposition to clinical management

Creator:

Michal Vrablík, Lukáš Zlatohlávek, Tomáš Štulc, Věra Adámková, Martina Prusíková, Schwarzová, L., Hubacek, J. A., and Richard Češka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cec626ef-711a-482a-a0f4-5958796b104e
uuid:cec626ef-711a-482a-a0f4-5958796b104e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, statiny, genetika, statins, genetics, Statin associated myopathy, definition, risk score, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Statin-associated myopathy (SAM) represents a broad spectrum of disorders from insignificant myalgia to fatal rhabdomyolysis. Its frequency ranges from 1-5 % in clinical trials to 15-20 % in everyday clinical practice. To a large extent, these variations can be explained by the definition used. Thus, we propose a scoring system to classify statin-induced myopathy according to clinical and biochemical criteria as 1) possible, 2) probable or 3) definite. The etiology of this disorder remains poorly understood. Most probably, an underlying genetic cause is necessary for overt SAM to develop. Variants in a few gene groups that encode proteins involved in: i) statin metabolism and distribution (e.g. membrane transporters and enzymes; OATP1B1, ABCA1, MRP, CYP3A4), ii) coenzyme Q10 production (e.g. COQ10A and B), iii) energy metabolism of muscle tissue (e.g. PYGM, GAA, CPT2) and several others have been proposed as candidates which can predispose to SAM. Pharmacological properties of individual statin molecules (e.g. lipophilicity, excretion pathways) and patients´ characteristics influence the likelihood of SAM development. This review summarizes current data as well as our own results., M. Vrablik, L. Zlatohlavek, T. Stulc, V. Adamkova, M. Prusikova, L. Schwarzova, J. A. Hubacek, R. Ceska., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false