Renal nerves participation in the effects of nitric oxide and ETA/ETB receptor inhibition in spontaneously hypertensive rats

Title:

Renal nerves participation in the effects of nitric oxide and ETA/ETB receptor inhibition in spontaneously hypertensive rats

Creator:

Girchev, Radoslav and Markova, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cfbb1a41-6559-4e0c-a8c4-980b67fe298f
uuid:cfbb1a41-6559-4e0c-a8c4-980b67fe298f
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, ledviny, exkrece, human physiology, kidneys, excretion, bilateral renal denervation, L-NAME, bosentan, SHR (spontaneously hypertensive rats), 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The influence of renal nerves on the effects of concurrent NO synthase inhibition (10 mg kg-1 b.w. i.v. L-NAME) and ETA/ETB receptor inhibition (10 mg kg-1 b.w. i.v. bosentan) on renal excretory function and blood pressure in conscious spontaneously hypertensive rats (SHR) was investigated. L-NAME increased blood pressure, urine flow rate, fractional excretion of sodium, chloride and phosphate in both normotensive Wistar rats and SHR with intact renal nerves (p<0.01). GFR or RBF did not change in any of the groups investigated. The effects of L-NAME on renal excretory function were markedly reduced by bosentan and the values returned to control level in the normotensive rats, while in SHR the values were reduced by bosentan, but they remained significantly elevated as compared to control level (p<0.05). The hypertensive response induced by L-NAME in SHR is partially due to activation of endogenous endothelins, but it does not depend on renal nerves. Chronic bilateral renal denervation abolished the effect of L-NAME on sodium and chloride excretion in normotensive rats, whereas it did not alter this effect in SHR. The participation of endogenous endothelins in changes of renal excretory function following NO synthase inhibition is diminished in SHR as compared to Wistar rats., R. Girchev, P. Markova., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:1

Harvested from:

CDK

Metadata only:

false