Hematopoiesis-Stimulating and Anti-Tumor Effects of Repeated Administration of Diclofenac in Mice with Transplanted Fibrosarcoma Cells

Title:

Hematopoiesis-Stimulating and Anti-Tumor Effects of Repeated Administration of Diclofenac in Mice with Transplanted Fibrosarcoma Cells

Creator:

Hofer, M., Zuzana Hoferová, Peter Fedoročko, and Naděžda O. Macková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cfd28ebc-b9a2-47a1-94e6-e14dcbf840c8
uuid:cfd28ebc-b9a2-47a1-94e6-e14dcbf840c8
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Diclofenac, Prostaglandins, Hematopoiesis, Fibrosarcoma, 14, and 612

Type:

article, studie, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Positive effects of repeated administration of diclofenac, an inhibitor of prostaglandin synthesis, in terms of prevention of tumor development and stimulation of hematopoiesis have been observed in C3H mice transplanted subcutaneously with G:5:113 fibrosarcoma cells. Fourteen-day treatment with diclofenac (3.75 mg/kg/day) started from day 5 after tumor cell transplantation. Measurements of tumors and hematological examinations were performed on day 30. The results strongly suggest the possibility that inhibitors of prostaglandin synthesis (non-steroidal anti-inflammatory drugs) may be used in oncological practice where the observed effects are highly desirable., M. Hofer, Z. Hoferová, P. Fedoročko, N. O. Macková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2002 Volume:51 | Number:6

Harvested from:

CDK

Metadata only:

false