Normocapnic high frequency oscillatory hyperventilation increases oxygenation in pigs

Title:

Normocapnic high frequency oscillatory hyperventilation increases oxygenation in pigs

Creator:

Karel Roubík, Jan Pachl, and Vladimír Zábrodský

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d1051328-314b-4327-b158-64962add4fbb
uuid:d1051328-314b-4327-b158-64962add4fbb

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, hyperventilation, normocapnia, oxygenation, high frequency ventilation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

High frequency oscillatory ventilation (HFOV), contrary to conventional ventilation, enables a safe increase in tidal volume (VT) without endangering alveoli by volutrauma or barotrauma. The aim of the study is to introduce the concept of normocapnic high frequency oscillatory hyperventilation and to assess its effect upon oxygen gain under experiment al conditions. Laboratory pigs (n=9) were investigated under total intravenous anesthesia in three phases. Phase 1: Initial volume controlled HFOV period. Phase 2 : Hyperventilation - VT was increased by (46 ± 12) % when compared to normocapnic VT during phase 1. All other ventilatory parameters were unchanged. A significant increase in PaO 2 (by 3.75 ± 0.52 kPa, p<0.001) and decrease in PaCO 2 (by -2.05 ± 0.31 kPa, p<0.001) were obtained. Phase 3: Normocapnia during hyperventilation was achiev ed by an iterative increase in the CO 2 fraction in the inspiratory gas by a CO2 admixture. All ventilatory parameters were unchanged. A significant increase in PaO2 (by 3.79 ± 0.73 kPa, p<0.001), similar to that which was observed in phase 2, was preserved in phase 3 whereas normocapnia was fully re-established. The concept of high frequency normocapnic hyperventilation offers a lung protective strategy that significantly improves oxygenation whilst preserving normocapnia., K. Roubík, J. Pachl, V. Zábrodský., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:5

Harvested from:

CDK

Metadata only:

false