Tolerance to acute ischemia in adult male and female spontaneously hypertensive rats

Title:

Tolerance to acute ischemia in adult male and female spontaneously hypertensive rats

Creator:

Josef Bešík, Ondrej Szárszoi, Jaroslav Kuneš, Ivan Netuka, Jan Malý, František Kolář, Jan Pirk, and Bohuslav Ošťádal

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d24cd4b9-5a84-4307-8fb5-cc8fb1c77e8e
uuid:d24cd4b9-5a84-4307-8fb5-cc8fb1c77e8e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, hypertenze, pohlavní rozdíly, physiology, hypertension, sex differences, srdeční tolerance, ischemické / reperfuzní poškození, spontánně hypertenzivní krysy, genderové rozdíly, cardiac tolerance, ischemia / reperfusion injury, spontaneously hypertensive rats, gender differences, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Clinical and experimental studies have repeatedly indicated that overloaded hearts have a higher vulnerability to ischemia/reperfusion injury. The aim of the present study was to answer the question whether the degree of tolerance to oxygen deprivation in hearts of spontaneously hypertensive rats (SHR) may be sex-dependent. For this purpose, adult SHR and their normotensive control Wistar Kyoto (WKY) rats were used. The isolated hearts were perfused according to Langendorff at constant pressure (proportionally adjusted to the blood pressure in vivo). Recovery of contractile parameters (left ventricular systolic, diastolic and developed pressure as well as the peak rate of developed pressure) was measured during reperfusion after 20 min of global no-flow ischemia in 5 min intervals. Mean arterial blood pressure was measured by direct puncture of carotid artery under light ether anesthesia in a separate group of animals. The degree of hypertension was comparable in both sexes of SHR. The recovery of contractile functions in SHR males and females was significantly lower than in WKY rats during the whole investigated period. There was no sex difference in the recovery of WKY animals; on the other hand, the recovery was significantly better in SHR females than in SHR males. It may be concluded that the hearts of female SHR are more resistant to ischemia/reperfusion injury as compared with male SHR. This fact could have important clinical implications for the treatment of cardiovascular disease in women., J. Bešík, O. Szárszoi, J. Kuneš, I. Netuka, J. Malý, F. Kolář, J. Pirk, B. Ošťádal., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:3

Harvested from:

CDK

Metadata only:

false