Tissue specific and variable collagen proliferation in Swiss albino mice treated with clenbuterol

Title:

Tissue specific and variable collagen proliferation in Swiss albino mice treated with clenbuterol

Creator:

Patiyal, S.N. and Katoch, S.S.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d321057f-e888-4d47-8ed8-9b331a9a0645
uuid:d321057f-e888-4d47-8ed8-9b331a9a0645

Subject:

Clenbueroll, Hydroxyproline, Collagen, and Endocardium

Type:

article, model:article, and TEXT

Description:

Chronic administration of clenbuterol, a beta-adrenoceptor agonist (2 mg/kg body weight/day for 30 days) to mice resulted in an increased body mass. Measurement of dry tissue mass suggested a protein anabolic effect in the gastrocnemius and heart. Quantitative estimation of collagen content, a non-contractile element as calculated from hydroxyproline assay revealed its proliferation in the gastrocnemius, cardiac ventricle, intestine and to some extent also in the kidney. Clenbuterol did not induce collagen proliferation in non-muscle tissues such as the lungs and liver. Histopathological examination of sections from treated ventricles showed an extensive collagen infiltration in the subendocardium and at myonecrosis sites.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2006 Volume:55 | Number:1

Harvested from:

CDK

Metadata only:

false