Mechanism of Na+ Deprivation-Induced Catecholamine Secretion From Freshly Isolated Bovine Adrenal Chromaffin Cells

Title:

Mechanism of Na+ Deprivation-Induced Catecholamine Secretion From Freshly Isolated Bovine Adrenal Chromaffin Cells

Creator:

Isosaki, M. and Nakashima, T.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d337af67-365b-4c6e-b966-1c2e32a8d376
uuid:d337af67-365b-4c6e-b966-1c2e32a8d376
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Na+-Ca2+ exchange, Na+ deprivation, Catecholamine secretion, Adrenal medulla · Chromaffin, 14, and 612

Type:

article, studie, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

We have studied the mechanism of Na+ deprivation-induced catecholamine secretion from freshly isolated bovine adrenal chromaffin cells. Na+ deprivation-induced catecholamine secretion depended on free extracellular Ca2+ concentrations and was almost parallel to 45Ca2+ influx into the cells under various experimental conditions. Furthermore, Na+ deprivation-induced 45Ca2+ influx and catecholamine secretion were actually induced by a relative Na+ concentration gradient across the plasma membrane, but not by simple omission of Na+ from the medium. These results indicate that the deprivation of Na+ from the medium changes the relative Na+ gradient across the plasma membrane and results in Ca2+ influx via a reverse mode of Na+-Ca2+ exchange rather than by inducing Ca2+ entry through Ca2+ channels by eliminating the competition between extracellular Na+ and Ca2+., M. Isosaki, T. Nakashima., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2002 Volume:51 | Number:4

Harvested from:

CDK

Metadata only:

false