Limbic irritability and chaotic neural response during conflicting stroop task in the patients with unipolar depression

Title:

Limbic irritability and chaotic neural response during conflicting stroop task in the patients with unipolar depression

Creator:

Bob, P. , Šusta, M. , Procházková-Večeřová, A., Kukleta, M. , Pavlát, J. , Jagla, F. , and Raboch, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d3f7b044-8e28-46d9-919e-267020c01592
uuid:d3f7b044-8e28-46d9-919e-267020c01592

Subject:

Depression, Stress, Limbic irritability, HRV, Lyapunov exponent, Chaos, and Anticonvulsants

Type:

article, model:article, and TEXT

Description:

According to recent findings activation of anterior cingulate co rtex (ACC) is related to detecting cognitive conflict. This conflict related activation elicits autonomic responses which can be assessed by psychophysiological measures such as heart rate variability calculated as beat to beat R-R interv als (RRI). Recent findings in neuroscience also suggest that cognitive conflict is related to specific nonlinear chaotic changes of the signal generated by neural systems. The present study used Stroop word-color test as an experimental approach to psychophysiological study of cognitive conflict in connection with RRI measurement, psychometric measurement of limbic irritability (LSCL-33), depression (BDI-II) and calculation of largest Lyapunov exponents in nonlinear data analysis of RRI time series. Significant correlation 0.61 between largest Lyapunov exponents and LSCL-33 found in this study indicate that a defect of neural inhibition during conflicting Stroop task is closely related to limbic irritability. Because limbic irritability is probably closely related to epileptiform abnormalities in the temporolimbic structures, this result might represent useful instrument for indication of anticonvulsant treatment in depressive patients who are resistant to antidepressant medication.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2006 Volume:55 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false