Endogenous LPS alters liver GH/IGF system gene expression and plasma lipoprotein lipase in goats

Title:

Endogenous LPS alters liver GH/IGF system gene expression and plasma lipoprotein lipase in goats

Creator:

Xie, Z. L., Ye, P. S., Zhang, S. K., Zhang, Y. S., and Shen, X. S.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d4ae69ba-68c5-42cc-ad6f-46724833e6f7
uuid:d4ae69ba-68c5-42cc-ad6f-46724833e6f7
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, lipoproteiny, játra, lipoproteins, liver, endotoxin lipopolysaccharide, GH/IGF system, lipoprotein lipase, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Endotoxin lipopolysaccharide (LPS) affects the ruminant health and animal performance. The main purposes of this study were to investigate the potential effects of GH/IGF system and lipoprotein lipase (LPL) concentration on resistance the circulating LPS concentration increased in liver with high concentrate diet treatment. Non- lactating goats were randomly allocated to two groups : a high -concentrate diet (HCD ) or a low - concentrate diet (LCD ) in cross over design and the blood collection at different time points after feeding at the end of the experiment. The average rumen pH was significantly reduced (P<0.05) , but the duration with pH was not more than 120 min in the HCD group. T he plasma LPL concentration w as significantly raised (P<0.05) . However, fr om 2 h onwards, LPS concentration was significantly reduced (P<0.0 1) in the H CD group compared with LCD group. In addition , the plasma IGF1 concentration and the hepatic i nsulin -like growth factor -1 receptor ( IGF1R) mRNA expression were markedly reduced (P<0.0 5). However, g rowth hormone (GH) secretion at 15, 30, and 45 min after feeding and growth hormone receptor (GHR) mRNA expression in the liver was significantly increased (P<0.05) in HCD group. The correlation analysis showed that the plasma LPL concentration was positive ly correlated with hepatic GHR mRNA expression (P<0.05) . Conversely, the plasma LPS concentration was negatively correlate d with LPL concentration (P<0.05). These findings reveal that alterations in GH/IGF system function in response to a hi gh -concentrate diet are accompanied by corresponding changes in systemic LPL in non -lactating goats ’ liver in presence of endogenous LPS stress., Z. L. Xie, P. S. Ye, S. K. Zhang, Y. S. Zhang, X. Z. Shen., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:5

Harvested from:

CDK

Metadata only:

false