Cardiac surgery increases serum concentrations of adipocyte fatty acid-binding protein and its mRNA expression in circulating monocytes but not in adipose tissue

Title:

Cardiac surgery increases serum concentrations of adipocyte fatty acid-binding protein and its mRNA expression in circulating monocytes but not in adipose tissue

Creator:

Tomáš Kotulák, Drapalova, J., Lips, M., Zdeňka Lacinová, Kramar, P., Riha, H., Ivan Netuka, Jan Malý, Jan Bláha, Jaroslav Lindner, Štěpán Svačina, Mraz, M., and Martin Haluzík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d980f7de-6e37-48ff-a6cc-f9b836a401b3
uuid:d980f7de-6e37-48ff-a6cc-f9b836a401b3

Subject:

Fyziologie člověka a srovnávací fyziologie, kardiochirurgie, inzulinová rezistence, cardiac surgery, insulin resistance, adipocyte fatty acid binding protein, adipose tissue, skeletal muscle, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Adipocyte fatty acid binding protein (A-FABP) is a novel adipokine involved in the regulation of lipid and glucose metabolism and inflammation. To evaluate its potential role in the development of postoperative hyperglycemia and insulin resistance we assessed A-FABP serum concentrations and mRNA expression in skeletal and myocardial muscle, subcutan eous and epicardial adipose tissue and peripheral monocytes in 11 diabetic and 20 age- and sex-matched non-diabetic patients undergoing elective cardiac surgery. Baseline serum A-FABP did not differ between the groups (31.1±5.1 vs. 25.9±4.6 ng /ml, p=0.175). Cardiac surgery markedly increased serum A-FABP in both groups with a rapid peak at the end of surgery foll owed by a gradual decrease to baseline values during the next 48 h with no significant difference between the groups at any timepoint. These trends were analogous to postoperative excursions of plasma glucose, insulin and selected proinflammatory markers. Cardiac surgery increased A-FABP mRNA expression in peripheral monocytes, while no effect was observed in adipose tissue or muscle. Our data suggest that circulating A-FABP might be involved in the development of acute perioperative stress response, insulin resistance and hyperglycemia of critically ill irrespectively of the presence of diab etes mellitus., T. Kotulak ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:1

Harvested from:

CDK

Metadata only:

false