Modeling the STDP symmetry-to-asymmetry transition in the presence of gabaergic inhibition

Title:

Modeling the STDP symmetry-to-asymmetry transition in the presence of gabaergic inhibition

Creator:

Cutsuridis , Vassilis, Cobb, Stuart, and graham , Bruce P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d9851317-f9df-4c88-9bb2-db0015fa82c0
uuid:d9851317-f9df-4c88-9bb2-db0015fa82c0

Subject:

Hippocampus, CA1 pyramidal neuron, computer model, STDP, GABA, LTP, LTD, and calcium

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Experimental studies have shown a symmetry-to-asymmetry transition of the spike-timing dependent plasticity (STDP) curve exists in the proximal stratum radiatum (SR) dendrite of the hippocampal CA1 pyramidal neuron, which is probably due to the presence of GABAergic inhibition [2, 3, 4]. A recent computational model predicted that symmetry-to-asymmetry transition is strongly dependent on the frequency and conductance value of GABA inhibition and that the largest long term potentiation (LTP) value and the two distinct long-term depression (LTD) tails of the symmetrical STDP curve are centred at +10 ms, +40 ms and -10 ms, respectively [8, 9]. In the present paper, we continue to investigate even further via computer simulations the effects of gamma frequency inhibition and its conductance value to the symmetry-to-asymmetry transition of the STDP profile in the SR dendrite and predict that the transition is even more robust when there is a temporal offset between the onsets of the pre-post excitatory stimulation and the GABAergic inhibition. The largest LTP value and the two distinct LTD tails are inversely proportional to the increase of GABA conductance.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Neural network world: international journal on neural and mass-parallel computing and information systems | 2009 Volume:19 | Number:5

Harvested from:

CDK

Metadata only:

false