Endocrine disruptors of the bisphenol and paraben families and bone metabolism

Title:

Endocrine disruptors of the bisphenol and paraben families and bone metabolism

Creator:

Jana Vítků, Lucie Kolátorová Sosvorová, Lenka Franeková, Jaroslav Blahoš, Marie Šimková, Michaela Dušková, Skodova, T, and Luboslav Stárka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:dac93d00-16dc-4cd5-9dec-3b01cd70271e
uuid:dac93d00-16dc-4cd5-9dec-3b01cd70271e
issn:0862-8408

Subject:

osteoporóza, bisfenol A, osteoporosis, bisphenol A, endocrine disruptor, paraben, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

After menopause, when estrogen levels decrease, there is room for the activity of anthropogenic substances with estrogenic properties - endocrine disruptors (EDs) - that can interfere with bone remodeling and changes in calcium-phosphate metabolism. Selected unconjugated EDs of the bisphenol group - BPA, BPS, BPF, BPAF, and the paraben family - methyl-, ethyl-, propyl-, butyl-, and benzyl-parabens - were measured by high performance liquid chromatography-tandem mass spectrometry in the plasma of 24 postmenopausal women. Parameters of calcium-phosphate metabolism and bone mineral density were assessed. Osteoporosis was classified in 14 women, and 10 women were put into the control group. The impact of EDs on calcium-phosphate metabolism was evaluated by multiple linear regressions. In women with osteoporosis, concentrations of BPA ranged from the lower limit of quantification (LLOQ) - 104 pg/ml and methyl paraben (MP) from LLOQ - 1120 pg/ml. The alternative bisphenols BPS, BPF and BPAF were all under the LLOQ. Except for MP, no further parabens were detected in the majority of samples. The multiple linear regression model found a positive association of BPA (β=0.07, p<0.05) on calcium (Ca) concentrations. Furthermore, MP (β=-0.232, p<0.05) was negatively associated with C-terminal telopeptide. These preliminary results suggest that these EDs may have effects on calcium-phosphate metabolism., J. Vitku, L. Kolatorova, L. Franekova, J. Blahos, M. Simkova, M. Duskova, T. Skodova, L. Starka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false