Ultrastructural characteristics of aortic endothelial cells in borderline hypertensive rats exposed to chronic social stress

Title:

Ultrastructural characteristics of aortic endothelial cells in borderline hypertensive rats exposed to chronic social stress

Creator:

Ľudmila Okruhlicová, Katarína Dlugošová, Mitašíková, M., and Iveta Bernátová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:dbb65ae7-e1f1-47df-b98f-2419a1da4159
uuid:dbb65ae7-e1f1-47df-b98f-2419a1da4159
issn:0862-8408

Subject:

Experimentální medicína, kardiovaskulární fyziologie, stres (psychologie), hypertenze, endotel, potkan, cardiovascular physiology, stress (psychology), hypertension, endothelium, Rattus norvegicus, social stress, ultrastructure, 14, and 616-092

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Genetic predisposition and social stress may represent important risk factors in etiology of hypertension associated with endothelial dysfunction. Perturbations of endothelial structural integrity are also critical for the pathogenesis of vascular diseases. We examined effect of chronic social stress on structure of aortic endothelium in bord erline hypertensive (BHR) and normotensive Wistar rats. Male BHR – offspring of Wistar mothers and SHR fathers and age-matched W were exposed to 6-week crowding stress (5 rats/cage, 200 cm2/rat). Aortic tissue was processed for electron microscopy and NO synthase activity measurement. Crowding stress significantly increased blood pressure in BHR compared to basal values (140±3 mm Hg vs. 130±3 mm Hg, p<0.05) and reduced enzyme activity by 37 % (p<0.01) in the aorta of BHR. Local slight structural alterations of endothelium were found in non-stressed BHR (p<0.001) when compared with Wistar rats. Chronic stress caused marked (p<0.005) subcellular injury of endothelial cells in aorta of BHR characterized by mitochondrial damage, presence of vacuoles, increased number of lysosomes, Weibel-Palade bodies, changes of intercellular connections and local disruption of endothelium, while only slight changes were seen in Wistar rats. Results suggest increased sensitivity of aortic endothelium of BHR to chronic crowding that may contribute to acceleration of arterial dysfunction., Ľ. Okruhlicová, K. Dlugošová, M. Mitašíková, I. Bernátová., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false