Effect of tapentadol on experimental model of orofacial pain - a pilot study

Title:

Effect of tapentadol on experimental model of orofacial pain - a pilot study

Creator:

Fricová, Jitka, Lainczová, Helena, Nedvídek, Jan, and Rokyta, Richard

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:dd65ea74-7700-4e98-b268-f846bf0935b5
uuid:dd65ea74-7700-4e98-b268-f846bf0935b5
doi:10.33549/physiolres.934603

Subject:

orofacial pain, experimental orofacial model, opioids, tapentadol, mechanical and thermal stimulation, and nociception

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Acute orofacial pain is associated with significant disability and has a detrimental impact on quality of life. Although various origins of the pain in trigeminal territory can be identified an odontogenic pathology is the most common cause of acute orofacial pain in patients. Due to complex pathophysiology drugs with multitarget action might provide beneficial effect in pain management. The aim of the present study was to experimentally examine the anti-nociceptive effects of tapentadol, an opioid agonist and a norepinephrine reuptake inhibitor (MOR/NRI), in our animal model of orofacial pain. We tested the effect of tapentadol at gradual doses of 1, 2 and 5 mg/kg during thermal and mechanical stimulation in the trigeminal area of adult rats. We observed that tapentadol exhibits antinociceptive effect at dosages of 2 mg/kg and 5 mg/kg and only in association with mechanical stimulation.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S533-S537

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 3

Harvested from:

CDK

Metadata only:

false