Voltage-dependent P/Q-type calcium channels at the frog neuromuscular junction

Title:

Voltage-dependent P/Q-type calcium channels at the frog neuromuscular junction

Creator:

Nurullin, L. F., Mukhitov, A. R., Tsentsevytsky, A. N., Petrova, N. V., Samigullin, D. V., Malomouzh, A. I., Bukharaeva, E. A., František Vyskočil, and Nikolsky, E. E.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:dda2c114-eee7-48be-bca4-edea40ddcabb
uuid:dda2c114-eee7-48be-bca4-edea40ddcabb

Subject:

Fyziologie člověka a srovnávací fyziologie, nervosvalový přenos, acetylcholin, neuromuscular transmission, acetylcholine, motor nerve terminal, acetylcholine release, N- and P/Q-type calcium channels, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

It is well known that antagonists of N-type voltage-gated calcium channels inhibit the evoked quan tal release of acetylcholine in amphibian neuromuscular synapses. This, however, does not exclude the functional expression of other types of voltage-gated calcium channels in these nerve terminals. Using immunocytochemistry, we detected the expression of the α1A subunit of P/Q-type calcium channels (that is otherwise typical of mammalian motor nerve endings) in the frog neuromuscular junction. In addition, we demonstrated that the P/Q-type channel blocker ω-agatoxin IVA (20 nM) reduced the action potential- induced calcium transient and significantly decreased both spontaneous and evoked mediator release. Our data indicates the functional expression of P/Q-type calcium channels in the frog motor nerve ending which participate in acetylcholine release., L. F. Nurullin ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:5

Harvested from:

CDK

Metadata only:

false