Mechanism of electrocardiographic T-wave flattening in diabetes mellitus: experimental and simulation study

Title:

Mechanism of electrocardiographic T-wave flattening in diabetes mellitus: experimental and simulation study

Creator:

Sedova, K. A., Azarov, J. E., Arteyeva, N. V., Ovechkin, A. O., Vaykshnorayte, M. A., Vityazev, M. A., Bernikova, O. G., Shmakov, D. N., and Kneppo, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:de016259-5361-4781-9f9c-dd00ae06bc43
uuid:de016259-5361-4781-9f9c-dd00ae06bc43

Subject:

diabetes, dispersion of repolarization, repolarization gradients, T-vector, and T-wave

Type:

article, model:article, and TEXT

Description:

In the present study we investigated the contribution of ventricular repolarization time (RT) dispersion (the maximal difference in RT) and RT gradients (the differences in RT in apicobasal, anteroposterior and interventricular directions) to T-wave flattening in a setting of experimental diabetes mellitus. In 9 healthy and 11 diabetic (alloxan model) open-chest rabbits, we measured RT in ventricular epicardial electrograms. To specify the contributions of apicobasal, interventricular and anteroposterior RT gradients and RT dispersion to the body surface potentials we determined T-wave voltage differences between modified upper- and lower-chest precordial leads (T-wave amplitude dispersions, TWAD). Expression of RT gradients and RT dispersion in the correspondent TWAD parameters was studied by computer simulations. Diabetic rabbits demonstrated flattened T-waves in precordial leads associated with increased anteroposterior and decreased apicobasal RT gradients (P<0.05) due to RT prolongation at the apex. For diabetics, simulations predicted the preserved T-vector length and altered sagittal and longitudinal TWAD proven by experimental measurements. T-wave flattening in the diabetic rabbits was not due to changes in RT dispersion, but reflected the redistributed ventricular repolarization pattern with prolonged apical repolarization resulting in increased anteroposterior and decreased apicobasal RT gradients.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:5

Harvested from:

CDK

Metadata only:

false