Ethanol consumption affects lipoprotein lipase gene expression in C57BL/6 mice

Title:

Ethanol consumption affects lipoprotein lipase gene expression in C57BL/6 mice

Creator:

Mudráková, E. and Jan Kovář

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:df765af2-6bdb-4656-9cae-1e445420b56b
uuid:df765af2-6bdb-4656-9cae-1e445420b56b
issn:0862-8408

Subject:

Patologie. Klinická medicína, experimentální medicína, lipoproteiny, ethanol, genová exprese, myši, experimental medicine, lipoproteins, gene expression, mice, apolipoprotein A-I, lipoproteinová lipáza, lipoprotein lipase, 14, and 616

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The activity of lipoprotein lipase (LPL) is increased after alcohol consumption and can contribute to an increased level of HDL-cholesterol, which is considered to play a key role in the ethanol-mediated protective effect against cardiovascular disease. The increase in HDL-cholesterol concentration can be also due to an ethanol-enhanced synthesis and secretion of apolipoprotein A-I (apo A-I) from hepatocytes. Therefore, the hypothesis that ethanol consumption affects the LPL and apo A-I gene (LPL and APOA1, respectively) expression was tested in male C57BL/6 mice drinking 5 % ethanol or water and fed a standard chow or high-fat (HF) diet for 4 weeks. The LPL expression was determined in the heart, epididymal and dorsolumbal adipose tissues, the APOA1 expression in the liver. Alcohol consumption did not affect lipid and lipoprotein concentrations in the serum. The LPL expression was increased in the heart of mice given ethanol and HF diet compared to mice on chow and ethanol (p<0.001) and was also increased in epididymal fat in mice given ethanol and HF diet compared to mice on water and HF diet (p<0.05). Neither LPL expression in dorsolumbal fat nor APOA1 expression in the liver were affected by ethanol consumption. Our data suggest that ethanol consumption upregulate LPL expression in a tissue- and diet-dependent manner., E. Mudráková, J. Kovář., and Obsahuje bibiografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:4

Harvested from:

CDK

Metadata only:

false