Pancreatic stellate cells - rising stars in pancreatic pathologies

Title:

Pancreatic stellate cells - rising stars in pancreatic pathologies

Creator:

Hrabák, Pavel, Kalousová, Marta, Krechler, Tomáš, and Zima, Tomáš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:dffe80a0-c9e0-4c37-8847-3f17a21b71cf
uuid:dffe80a0-c9e0-4c37-8847-3f17a21b71cf
doi:10.33549/physiolres.934783

Subject:

pancreatic stellate cells, pancreatic cancer, diabetes mellitus, chronic pancreatitis, and tumor microenvironment

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Pluripotent pancreatic stellate cells (PSCs) receive growing interest in past decades. Two types of PSCs are recognized – vitamin A accumulating quiescent PSCs and activated PSCs- the main producents of extracellular matrix in pancreatic tissue. PSCs plays important role in pathogenesis of pancreatic fibrosis in pancreatic cancer and chronic pancreatitis. PSCs are intensively studied as potential therapeutical target because of their important role in developing desmoplastic stroma in pancreatic cancer. There also exists evidence that PSC are involved in other pathologies like type-2 diabetes mellitus. This article brings brief characteristics of PSCs and recent advances in research of these cells.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S597-S616

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 4

Harvested from:

CDK

Metadata only:

false