Genetic susceptibility to type 1 diabetes mellitus in humans

Title:

Genetic susceptibility to type 1 diabetes mellitus in humans

Creator:

Daniela Kantárová and Milan Buc

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e0533900-191b-432b-b9ad-c65ce5bbaef3
uuid:e0533900-191b-432b-b9ad-c65ce5bbaef3
issn:0862-8408

Subject:

Patologie. Klinická medicína, imunologie, inzulin, diabetes mellitus, immunology, insulin, CD25, CTLA4, HLA (human leukocyte antigens), IDDM (insulin-dependent diabetes mellitus), type 1 diabetes mellitus, PTPN22 (protein tyrosine phosphatase non-receptor type 22), 14, and 616

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Type 1 diabetes mellitus (DM 1A) is an autoimmune disease belonging to the most frequent chronic diseases of the childhood and young adults. DM 1A results from immune-mediated destruction of the insulin-producing beta cells of the pancreas. It is a genetically determined disease and many genes or genetic regions were found to be associated with its induction. In addition to the insulin-dependent diabetes mellitus 1 (IDDM1) gene, which marks the HLA region, and IDDM2 which marks the insulin gene, significant associations of DM 1A to other IDMM genes or genetic regions we reported. We shortly review recent achievements in the field, and the state of current knowledge., D. Kantárová, M. Buc., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:3

Harvested from:

CDK

Metadata only:

false