Effect of an increase in coronary perfusion on transmural ventricular repolarization

Title:

Effect of an increase in coronary perfusion on transmural ventricular repolarization

Creator:

Zhang, Z.-Z., Bin He, and Wang, Lexin

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e1d9ef32-cd14-48ec-aca5-fa20be8f44e5
uuid:e1d9ef32-cd14-48ec-aca5-fa20be8f44e5
issn:0862-8408

Subject:

Patologie. Klinická medicína, kardiologie, srdeční arytmie, oxid dusnatý, cardiology, cardiac arrhythmia, nitric oxide, repolarization, activation-recovery interval, coronary flow, 14, and 616

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The effect of increased coronary flow on transmural ventricular repolarization was investigated in six pentobabital-anesthetized sheep. Fresh blood at 10 ml/min was injected into the left circumflex coronary artery (LCX) in addition to the normal coronary flow. Unipolar electrocardiograms were simultaneously registered from epicardium, mid-myocardium and endocardium with fine plunge needles. Activation-recovery interval (ARI) was measured from the unipolar electrocardiograms and was used for estimating the ventricular repolarization duration. It was found that intracoronary blood injection (n=3) prolonged ARI in the epicardium, mid-myocardium and endocardium by an average of 34 ± 16, 28 ± 18 and 25 ± 13 ms, respectively (p<0.01). Pretreatment with nitro-L-arginine (n=3), a nitric synthase inhibitor, diminished the flow-induced ARI prolongation across the ventricular wall. In conclusion, an increase in coronary flow lengthens the duration of transmural ventricular repolarization. These effects appear to be mediated by nitric oxide from the coronary endothelium., Y.-Z. Zhang, B. He, L.-X. Wang., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:3

Harvested from:

CDK

Metadata only:

false