Comparison of the effects of ketamine-dexmedetomidine and sevoflurane-sufentanil anesthesia on cardiac biomarkers after cardiac surgery: an observational study

Title:

Comparison of the effects of ketamine-dexmedetomidine and sevoflurane-sufentanil anesthesia on cardiac biomarkers after cardiac surgery: an observational study

Creator:

Říha, H., Tomáš Kotulák, Březina, A., Hess, L., Kramář, P., Ondrej Szárszoi, Ivan Netuka, and Jan Pirk

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e271e8e5-6a31-48fb-8c94-1c4e379411af
uuid:e271e8e5-6a31-48fb-8c94-1c4e379411af

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, myocardial ischemia-reperfusion injury, ketamine, dexmedetomidine, sevoflurane, cardiac troponin I, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Inhalational anesthetics have demonstrated cardioprotective effects against myocardial ischemia-reperfusion injury. Clinical studies in cardiac surgery have supported these findings, although not with the consistency demonstrated in experimental studies. Recent investigations have questioned the advantages of inhalational over intravenous anesthetics with respect to cardiac protection. Ketamine has been shown to be comparable with sufentanil, and has even demonstrated anti-inflammatory properties. Dexmedetomidine has been established as a sedative/anesthetic drug with analgesic properties, and has also demonstrated myocardial protective effects. In this retrospective observational study, the influence of ketamine-dexmedetomidinebased anesthesia (KET-DEX group; n=17) on the release of cardiac biomarkers was compared with that of sevofluranesufentanil-based anesthesia (SEVO group; n=21) in patients undergoing elective coronary artery bypass grafting. Compared with the SEVO group, the KET-DEX group exhibited significantly reduced cardiac troponin I (2.22±1.73 vs. 3.63±2.37 µg/l; P=0.02) and myocardial fraction of creatine kinase (CK-MB) levels (12.4±10.4 vs. 20.3±11.2 µg/l; P=0.01) on the morning of the first postoperative day. Furthermore, cardiac troponin I release, evaluated as the area under the curve, was significantly reduced in the KET-DEX group (32.1±20.1 vs. 50.6±23.2; P=0.01). These results demonstrate the cardioprotective effects of ketamine-dexmedetomidine anesthesia compared with those of sevoflurane-sufentanil anesthesia., H. Říha ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:1

Harvested from:

CDK

Metadata only:

false