Responsiveness and habituation of soluble ICAM-1 to acute psychosocial stress in men: determinants and effect of stress-hemoconcentration

Title:

Responsiveness and habituation of soluble ICAM-1 to acute psychosocial stress in men: determinants and effect of stress-hemoconcentration

Creator:

von Känel, Roland, Preckel, D., Kudielka, B. M., and Fischer, J. E.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e2b7c4fe-1862-47d6-9936-e781c931446e
uuid:e2b7c4fe-1862-47d6-9936-e781c931446e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, psychobiologie, adheze, stres (psychologie), psychobiology, adhesion, stress (psychology), HPA osa, hypothalamic-pituitary-adrenal axis, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

We studied the psychophysiology of soluble intercellular adhesion molecule-1 (sICAM-1) in 25 apparently healthy middle-aged men who underwent an acute psychosocial stressor three times with one week apart. Measures of the biological stress response were obtained at week one and three. The magnitude of the sICAM-1 stress response showed no habituation between individual visits. At week one, cognitive stress appraisal independently predicted integrated sICAM-1 area under the curve (AUC) between rest, immediately post-stress, and 45 min and 105 min post-stress (β=0.67, p=0.012, ΔR2=0.41). Diastolic blood pressure AUC (β=-0.45, p=0.048, ΔR2=0.21) and heart rate AUC (β=0.44, p=0.055, ΔR2=0.21) were independent predictors of sICAM-1 AUC at week three. Adjustment for hemoconcentration yielded a decrease in sICAM-1 levels from rest to post-stress (p<0.001). Stress responsiveness of plasma sICAM-1 was predicted by stress perception and hemodynamic reactivity and affected by stress-hemoconcentration but unrelated to cortisol reactivity and not readily adapting to repeated stress., R. von Känel, D. Preckel, B. M. Kudielka, J. E. Fischer., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:5

Harvested from:

CDK

Metadata only:

false