Effects of 5-hydroxytryptamine on the short-circuit current across the small intestine of the gerbil (Gerbillus cheesmani) in different dietary states

Title:

Effects of 5-hydroxytryptamine on the short-circuit current across the small intestine of the gerbil (Gerbillus cheesmani) in different dietary states

Creator:

Al-Balool, F. Y.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e3727c4f-4aa1-4b6a-9019-9c05277f3011
uuid:e3727c4f-4aa1-4b6a-9019-9c05277f3011
issn:0862-8408

Subject:

Biologické vědy, fyziologie živočichů, pískomilové, hladovění, zkratový, animal physiology, gerbils, starvation, malnutrition, 5-hydroxytryptamin, tetrodotoxin, short circuit-current, 2, and 57/59

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The effects of serosally added 5-hydroxytryptamine (5-HT, 100 μM) on the short circuit-current (Isc) across jejunum and ileum taken from fed, starved and undernourished (Gerbillus cheesmani) were investigated. The effects of the neurotoxin, tetrodotoxin (TTX, 10 μM) on the basal Isc as well as on the maximum increase in Isc induced by 5-HT were also studied. There were regional variations in the basal Isc as well as in the way by which the small intestine responds to 5-HT. The basal Isc was greater in jejunum than in ileum and such differences were TTX-sensitive. The maximum increase in Isc, which results from addition of 5-HT, was higher in jejunum than in ileum under all three feeding conditions. TTX reduced the maximum increase in Isc induced by 5-HT across stripped and intact intestine of the two regions in the three nutritional states. The 5-HT-induced Isc in the jejunum of both starved and undernourished gerbils and in the ileum of starved animals was the function of both submucosal and myenteric plexus. In jejunum and ileum taken from starved and undernourished gerbils the 5-HT-induced Isc was both chloride- and bicarbonate-dependent. Thus the results indicated that both starvation and undernourishment increase that response and such increases were TTX-sensitive and both chloride- and bicarbonate-dependent., F. Y. Al-Balool., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:5

Harvested from:

CDK

Metadata only:

false