T2D risk haplotypes of the TCF7L2 gene in the czech population sample: the association with free fatty acids composition

Title:

T2D risk haplotypes of the TCF7L2 gene in the czech population sample: the association with free fatty acids composition

Creator:

Josef Včelák, Daniela Vejražková, Markéta Vaňková, Lukášová, P., Bradnová, O., Hálková, T., Bešťák, J., Kateřina Andělová, Hana Kvasničková, Petra Hoskovcová, Karel Vondra, Jana Vrbíková, and Běla Bendlová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e3ec150e-ec69-407a-8e54-338ae56d9ed3
uuid:e3ec150e-ec69-407a-8e54-338ae56d9ed3

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, TCF7L2, haplotypes, type 2 diabetes, gestational diabetes, genetics, polycystic ovary syndrome, diabetes risk, free fatty acids, polyunsaturated fatty acids, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

The association of transcription factor 7-like 2 (TCF7L2) gene variants with the pathogenesis of T2D, gestational diabetes and polycystic ovary syndrome (PCOS) was examined. The study involved 1460 individuals: 347 T2D patients (D); 261 gestational diabetics (G); 147 offspring of T2D (O); 329 women with PCOS, and 376 controls (C). The SNPs: rs7901695; rs7903146; rs12255372 in the TCF7L2 gene were genotyped. Anthropometric and biochemical parameters, oGTT derived indices were assessed. In addition, free fatty acids (FFAs) were evaluated in 183 non-diabetic women. The CTT haplotype showed the strongest association with T2D with OR 1.57, p=0.0003. The frequency of the CTT/CTT haplotype was decreasing in following order: D 10.6, O 9.5, G 6.1, C 5.3 and PCOS 4.9 [%]. Among CTT carriers, significantly decreased levels of oGTT-stimulated insulin and C-peptide as well as proportions of fasting PUFAs were observed. The carriership of CTG/TCG was associated with gestational diabetes, OR 2.59, p=0.036. The association of TCF7L2 haplotypes with T2D and gestational diabetes but not with PCOS was confirmed. Novel association of TCF7L2 with FFAs composition was found., J. Včelák ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:3

Harvested from:

CDK

Metadata only:

false