Pulmonary protective effects of hyberbaric oxygen and N-acetylcysteine treatment in necrotizing pancreatitis

Title:

Pulmonary protective effects of hyberbaric oxygen and N-acetylcysteine treatment in necrotizing pancreatitis

Creator:

Balkan, A., Balkan, M. , Yasar, M., Korkmaz, A., Erdem, O., Kilic, S., Kutsal, O., and Bilgic, H.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e41cffed-b60a-434d-bd4b-b46bfba40985
uuid:e41cffed-b60a-434d-bd4b-b46bfba40985

Subject:

Acute necrotizing pancreatitis, Lung injury, Hyperbaric oxygen, and Reactive oxygen species

Type:

article, model:article, and TEXT

Description:

The purpose of this study is to analyze the protective effect of combining N-acetylcysteine (NAC) and hyberbaric oxygen (HBO) treatment in the lung tissue during acute pancreatitis. Sixty Sprague-Dawley male rats were randomly divided into five groups; Group I; Control group (n=12), Gr oup II; pancreatitis group (n=12), Group III; pancreatitis + NAC treatment group (n=12), Group IV; pancreatitis + HBO treatment group (n=12), Group V; pancreatitis + HBO + NAC treatment group (n=12). HBO was applied postoperatively for 5 days, twice a day at 2.5 fold absolute atmospheric pressure for 90 min. Lung tissue was obtained for measuring malondialdehyde (MDA), superoxide dismutase (Cu/Zn-SOD) and glutathione peroxidase (GSH-Px) levels along with histopathological tissue examinations. This study showed that all three treated groups (HBO alone, NAC alone and combined HBO+NAC treatment) had pulmonary protective effects during acute necrotizing pancreatitis.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2006 Volume:55 | Number:1

Harvested from:

CDK

Metadata only:

false