Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high-fat diet

Title:

Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high-fat diet

Creator:

Sena, C. M., Louro, T., Matafome, P., Nunes, E., Monteiro, P., and Seiça, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e6759202-2d17-44a6-a868-7ffc281876eb
uuid:e6759202-2d17-44a6-a868-7ffc281876eb

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, endotel, oxid dusnatý, diabetes mellitus, oxidační stres, physiology, endothelium, nitric oxide, oxidative stress, gliclazide, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Diabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial function in Goto-Kakizaki rats (GK), an animal model of type 2 diabetes fed an atherogenic diet for 4 months. We evaluated the influence of gliclazide on both metabolic and oxidative status and NO-mediated vasodilation. GKAD rats showed increased oxidative stress and impaired endothelium-dependent vasodilation. GKAD rats treated with gliclazide showed increased sensitivity to NO-mediated vasodilation, a significant decrease in fasting glycemia and insulinemia, and a significant decrease in systemic oxidative stress. In conclusion, our results suggest that gliclazide treatment improves NO-mediated vasodilation in diabetic GK rats with dyslipidemia probably due to its antioxidant effects, although we cannot rule out substantial benefits due to a reduction in fasting blood glucose. The availability of a compound that simultaneously decreases hyperglycemia, hyperinsulinemia, and inhibits oxidative stress is a promising therapeutic candidate for the prevention of vascular complications of diabetes., C. M. Sena ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:2

Harvested from:

CDK

Metadata only:

false