Late effect of early hypoxic disturbance in the rat heart: gender differences

Title:

Late effect of early hypoxic disturbance in the rat heart: gender differences

Creator:

Ivan Netuka, Ondrej Szárszoi, Jan Malý, Hynek Říha, Turek, D., Ivana Ošťádalová, and Bohuslav Ošťádal

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e6e8c6db-be02-4721-8929-a4912820d719
uuid:e6e8c6db-be02-4721-8929-a4912820d719

Subject:

Fyziologie člověka a srovnávací fyziologie, gender, ischemie, ischemia, perinatal hypoxia, isolated rat heart, reperfusion injury, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Perinatal hypoxemia may have serious long-term effects on the adult cardiovascular system and may lead to sex-dependent changes in cardiac tolerance to acute ischemia in adult life. The aim of the study was to answer the question whether gonadectomy of the male and female rats in the early phase of ontogenetic development affects the late effect of perinatal hypoxia. Pregnant Wistar rats were placed into a normobaric hypoxic chamber (12 % O2) 7 days before the expected date of delivery. Newborn pups were kept in the chamber with their mothers for another 5 days after birth. After hypoxic exposure all animals were kept for 3 months in room air. Some of the pups were gonadectomized right after removal from the hypoxic chamber. Ventricular arrhythmias were assessed on isolated perfused hearts. Castration did not influence arrhythmogenesis in the adult normoxic or perinatally hypoxic female hearts. Nevertheless, the number of arrhythmias was decreased in perinatally hypoxic gonadectomized males. In conclusion, we have shown that perinatal normobaric hypoxia increased cardiac tolerance to acute ischemia in adult male rats; however, it had no late effect in females. Gonadectomy did not affect arrhythmogenesis in both normoxic and hypoxic female hearts, whereas in males significantly decreased the number of arrhythmias., I. Netuka ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:1

Harvested from:

CDK

Metadata only:

false